Publications
38 peer-reviewed papers and 4 preprints listing Christian Schlein as an author. Auto-aggregated from PubMed and Crossref at build time.
- 2026 Molecular metabolism PMID 41935828
The conjugation-resistant bile acid norUDCA cures liver fibrosis but impairs systemic energy metabolism
Evangelakos I, Verkade E, Rohde JK, Zaufel A, Vargek M, Heine M, Worthmann A, Graute S, Manka Fuh M, Gunasekaran K, Kumari M, Schwinge D, von Bergen M, Rolle-Kampczyk U, Engelmann B, Breinbauer R, Fuerst R, Saleem U, de Boer JF, , Hansen A, Scheja L, Kuipers F, Moustafa T, Heeren J
- 2026 JCI insight PMID 41729082
Structural modeling and functional characterization of a novel gain-of-function TLR8 variant causing severe inflammatory syndrome
Skenteris NT, Luttermann E, Nair S, Evangelakos I, Pujantell M, Eggers M, Hausmann F, Bérouti M, Padoan B, Flomm FJ, Claussen JM, Grünhagel B, Salfelder A, Beifuss B, Biskup S, Blümke P, Rading K, Hildebrandt H, Matschl U, Giesemann-Jansen S, Hennesen J, Nikolaev VO, Kutsche M, Kubisch C, Koch-Nolte F, Tomas NM, Tolosa E, Lütgehetmann M, Stahl FR, Hornung V, Bunders MJ, , Topf M, Kötter I, Altfeld M
- 2026 Nature medicine Correction PMID 41484224
Author Correction: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, , Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH
- 2026 Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology PMID 41061941
Thoracic aortic diseases: Identification of diagnostic biomarkers using proteomic analysis
Arndt N, Mair T, Riedner M, Biabani A, Voß H, Schlüter H, Förster L, Knochenhauer T, Sachse M, Beyer M, Leonhardt M, von Kodolitsch Y, , Sauter G, Nauth T, Naito S, Girdauskas E, Reichenspurner H, Detter C, Rosenberger G, Demal TJ
- 2026 Brain : a journal of neurology PMID 40302207
Pleiotropic effects of MORC2 derive from its epigenetic signature
Peymani F, Ebihara T, Smirnov D, Kopajtich R, Ando M, Bertini E, Carrozzo R, Diodato D, Distelmaier F, Fang F, Ghezzi D, Hempel M, Iwanicka-Pronicka K, Klopstock T, Stenton SL, Lamperti C, Liu Z, Murtazina A, Okamoto Y, Okazaki Y, Piekutowska-Abramczuk D, Rötig A, Ryzhkova O, , Shagina O, Takashima H, Tsygankova P, Zech M, Meitinger T, Shimura M, Murayama K, Prokisch H
- 2025 EMBO reports PMID 41261284
Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue
Jaeckstein MY, Fischer AW, Rissiek B, Staehler T, Heine M, Behrens J, Mann O, Pfeifer A, Magnus T, , Worthmann A, Scheja L, Koch-Nolte F, Heeren J
- 2025 Genome medicine PMID 40963120
Evaluating genome sequencing strategies: trio, singleton, and standard testing in rare disease diagnosis
Kaschta D, Post C, Gaass F, Al-Tawil M, Arriens V, Balachandran S, Bäumer T, Berge V, Birgel F, Dalski A, Dittmar M, Franke A, Franzenburg S, Fuß J, Gehring B, Gembicki R, Greiten B, Grohte K, Hanker B, Händler K, Harder L, Hellenbroich Y, Herget T, Herrmann G, Hiort O, Hoff K, Hoffmann B, Hornig N, Hüning I, Kautza-Lucht M, Köhler J, Liegmann AS, Lisfeld J, Löscher BS, Margraf NG, Meyenborg M, Möllring A, Muhle H, Penas EMM, Nommels H, Papingi D, Poggenburg I, Pozojevic J, Rosenstiel P, Recke A, Roberts K, Rösler L, Rust F, Salewski MB, Schau-Römer K, , Sreenivasan VKA, Toutouna L, Utermann-Thüsing C, van der Ven AT, Volk AE, Wehnert J, Wilson S, Woitschach R, Yumiceba V, Zühlke C, Münchau A, Brüggemann N, Vater I, Caliebe A, Nagel I, Spielmann M
- 2025 Nature genetics Correction PMID 40555819
Author Correction: Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings
Schmidt A, Danyel M, Grundmann K, Brunet T, Klinkhammer H, Hsieh TC, Engels H, Peters S, Knaus A, Moosa S, Averdunk L, Boschann F, Sczakiel HL, Schwartzmann S, Mensah MA, Pantel JT, Holtgrewe M, Bösch A, Weiß C, Weinhold N, Suter AA, Stoltenburg C, Neugebauer J, Kallinich T, Kaindl AM, Holzhauer S, Bührer C, Bufler P, Kornak U, Ott CE, Schülke M, Nguyen HHP, Hoffjan S, Grasemann C, Rothoeft T, Brinkmann F, Matar N, Sivalingam S, Perne C, Mangold E, Kreiss M, Cremer K, Betz RC, Mücke M, Grigull L, Klockgether T, Spier I, Heimbach A, Bender T, Brand F, Stieber C, Morawiec AM, Karakostas P, Schäfer VS, Bernsen S, Weydt P, Castro-Gomez S, Aziz A, Grobe-Einsler M, Kimmich O, Kobeleva X, Önder D, Lesmann H, Kumar S, Tacik P, Bhasin MA, Incardona P, Lee-Kirsch MA, Berner R, Schuetz C, Körholz J, Kretschmer T, Di Donato N, Schröck E, Heinen A, Reuner U, Hanßke AM, Kaiser FJ, Manka E, Munteanu M, Kuechler A, Cordula K, Hirtz R, Schlapakow E, , Lisfeld J, Kubisch C, Herget T, Hempel M, Weiler-Normann C, Ullrich K, Schramm C, Rudolph C, Rillig F, Groffmann M, Muntau A, Tibelius A, Schwaibold EMC, Schaaf CP, Zawada M, Kaufmann L, Hinderhofer K, Okun PM, Kotzaeridou U, Hoffmann GF, Choukair D, Bettendorf M, Spielmann M, Ripke A, Pauly M, Münchau A, Lohmann K, Hüning I, Hanker B, Bäumer T, Herzog R, Hellenbroich Y, Westphal DS, Strom T, Kovacs R, Riedhammer KM, Mayerhanser K, Graf E, Brugger M, Hoefele J, Oexle K, Mirza-Schreiber N, Berutti R, Schatz U, Krenn M, Makowski C, Weigand H, Schröder S, Rohlfs M, Vill K, Hauck F, Borggraefe I, Müller-Felber W, Kurth I, Elbracht M, Knopp C, Begemann M, Kraft F, Lemke JR, Hentschel J, Platzer K, Strehlow V, Abou Jamra R, Kehrer M, Demidov G, Beck-Wödl S, Graessner H, Sturm M, Zeltner L, Schöls LJ, Magg J, Bevot A, Kehrer C, Kaiser N, Turro E, Horn D, Grüters-Kieslich A, Klein C, Mundlos S, Nöthen M, Riess O, Meitinger T, Krude H, Krawitz PM, Haack T, Ehmke N, Wagner M
- 2025 The Journal of biological chemistry PMID 40345590
Covalent binding of thioredoxin to TXNIP is required for diet-induced insulin resistance in the liver
Dagdeviren S, Hoang MF, Wang J, Goldberger T, Yu AM, Blair SJ, Benoit JC, Ricci-Blair EM, Melnik VY, Kim BY, Tauer LA, Scholz JJ, Worthmann A, , Stone D, Deuitch NT, Aksentijevich I, Schnappauf O, Whited JL, Kim JK, Lee RT
- 2025 Preprint · medRxiv
Maternal IGHG locus duplications impair infants' passive immunity
Belios I, Zazara DE, Evangelakos I, Hambach J, Siegl T, Riecken K, Albrecht M, Müller C, Spohn M, Wieczorek A, Rading K, Thiele K, Giannou AD, Zarogiannis SG, Ledée N, Wang W, Gijze S, Nouta J, Manalastas-Cantos K, Graf I, Urbschat C, Tallarek AC, Topf M, Stahl F, Koch-Nolte F, Lütgehetmann M, Wuhrer M, Alawi M, Becker M, Addo MM, Diemert A, , Arck PC
- 2025 Preprint · bioRxiv Senior author
A simple, cost efficient assay for assessing the functional impact of single and multi-gene variant combinations
Telge M, Evangelakos I,
- 2025 Preprint · medRxiv Senior author
TXNIP is a critical regulator of human cardiometabolic health
Scholz J, Piel S, Evangelakos I, Müller C, Karall D, Reinhart-Steininger B, Steinbrücker K, Stulnig T, Rohde J, Mayr J, Wagner M, Biabani A, Mair T, Müller K, Schlüter H, Weidemann S, Chirico V, Weiler-Normann C, Hagel C, Knisely A, Heeren J, Schoser B, Kubisch C, Hempel M, Prokisch H, Wortmann S, Worthmann A,
- 2024 Nature communications PMID 39256359
Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors
Willim J, Woike D, Greene D, Das S, Pfeifer K, Yuan W, Lindsey A, Itani O, Böhme AL, Tibbe D, Hönck HH, Hassani Nia F, Undiagnosed Diseases Network, Zech M, Brunet T, Faivre L, Sorlin A, Vitobello A, Smol T, Colson C, Baranano K, Schatz K, Bayat A, Schoch K, Spillmann R, Davis EE, Conboy E, Vetrini F, Platzer K, Neuser S, Gburek-Augustat J, Grace AN, Mitchell B, Stegmann A, Sinnema M, Meeks N, Saunders C, Cadieux-Dion M, Hoyer J, Van-Gils J, de Sainte-Agathe JM, Thompson ML, Bebin EM, Weisz-Hubshman M, Tabet AC, Verloes A, Levy J, Latypova X, Harder S, Silverman GA, Pak SC, Schedl T, Freson K, Mumford A, Turro E, , Shashi V, Kreienkamp HJ
- 2024 Nature genetics PMID 39039281
Next-generation phenotyping integrated in a national framework for patients with ultrarare disorders improves genetic diagnostics and yields new molecular findings
Schmidt A, Danyel M, Grundmann K, Brunet T, Klinkhammer H, Hsieh TC, Engels H, Peters S, Knaus A, Moosa S, Averdunk L, Boschann F, Sczakiel HL, Schwartzmann S, Mensah MA, Pantel JT, Holtgrewe M, Bösch A, Weiß C, Weinhold N, Suter AA, Stoltenburg C, Neugebauer J, Kallinich T, Kaindl AM, Holzhauer S, Bührer C, Bufler P, Kornak U, Ott CE, Schülke M, Nguyen HHP, Hoffjan S, Grasemann C, Rothoeft T, Brinkmann F, Matar N, Sivalingam S, Perne C, Mangold E, Kreiss M, Cremer K, Betz RC, Mücke M, Grigull L, Klockgether T, Spier I, Heimbach A, Bender T, Brand F, Stieber C, Morawiec AM, Karakostas P, Schäfer VS, Bernsen S, Weydt P, Castro-Gomez S, Aziz A, Grobe-Einsler M, Kimmich O, Kobeleva X, Önder D, Lesmann H, Kumar S, Tacik P, Bhasin MA, Incardona P, Lee-Kirsch MA, Berner R, Schuetz C, Körholz J, Kretschmer T, Di Donato N, Schröck E, Heinen A, Reuner U, Hanßke AM, Kaiser FJ, Manka E, Munteanu M, Kuechler A, Cordula K, Hirtz R, Schlapakow E, , Lisfeld J, Kubisch C, Herget T, Hempel M, Weiler-Normann C, Ullrich K, Schramm C, Rudolph C, Rillig F, Groffmann M, Muntau A, Tibelius A, Schwaibold EMC, Schaaf CP, Zawada M, Kaufmann L, Hinderhofer K, Okun PM, Kotzaeridou U, Hoffmann GF, Choukair D, Bettendorf M, Spielmann M, Ripke A, Pauly M, Münchau A, Lohmann K, Hüning I, Hanker B, Bäumer T, Herzog R, Hellenbroich Y, Westphal DS, Strom T, Kovacs R, Riedhammer KM, Mayerhanser K, Graf E, Brugger M, Hoefele J, Oexle K, Mirza-Schreiber N, Berutti R, Schatz U, Krenn M, Makowski C, Weigand H, Schröder S, Rohlfs M, Vill K, Hauck F, Borggraefe I, Müller-Felber W, Kurth I, Elbracht M, Knopp C, Begemann M, Kraft F, Lemke JR, Hentschel J, Platzer K, Strehlow V, Abou Jamra R, Kehrer M, Demidov G, Beck-Wödl S, Graessner H, Sturm M, Zeltner L, Schöls LJ, Magg J, Bevot A, Kehrer C, Kaiser N, Turro E, Horn D, Grüters-Kieslich A, Klein C, Mundlos S, Nöthen M, Riess O, Meitinger T, Krude H, Krawitz PM, Haack T, Ehmke N, Wagner M
- 2024 Cell reports. Medicine PMID 38901430
Intergenic risk variant rs56258221 skews the fate of naive CD4(+) T cells via miR4464-BACH2 interplay in primary sclerosing cholangitis
Poch T, Bahn J, Casar C, Krause J, Evangelakos I, Gilladi H, Kunzmann LK, Laschtowitz A, Iuso N, Schäfer AM, Liebig LA, Steinmann S, Sebode M, Folseraas T, Engesæter LK, Karlsen TH, Franke A, Hubner N, , Galun E, Huber S, Lohse AW, Gagliani N, Schwinge D, Schramm C
- 2024 Nature communications Senior author PMID 38167725
Fatty acid synthesis suppresses dietary polyunsaturated fatty acid use
Worthmann A, Ridder J, Piel SYL, Evangelakos I, Musfeldt M, Voß H, O'Farrell M, Fischer AW, Adak S, Sundd M, Siffeti H, Haumann F, Kloth K, Bierhals T, Heine M, Pertzborn P, Pauly M, Scholz JJ, Kundu S, Fuh MM, Neu A, Tödter K, Hempel M, Knippschild U, Semenkovich CF, Schlüter H, Heeren J, Scheja L, Kubisch C,
- 2023 Preprint · bioRxiv Senior author
Mitochondrial fatty acid synthesis is essential for coordinated energy transformation
Haumann F, Evangelakos I, Worthmann A, Liebold I, Kotschi S, Bischoff A, Neuhofer C, Schweizer M, Heine M, Büchner B, Klopstock T, Prehn C, Dyar K, Prokisch H, Bosurgi L, Heeren J, Bartelt A, Kubisch C,
- 2022 Pigment cell & melanoma research PMID 35912549
Clinical and pathological characteristics of familial melanoma with germline TERT promoter variants
Zaremba A, Meier F, , Jansen P, Lodde G, Song M, Kretz J, Möller I, Stadtler N, Livingstone E, Zimmer L, Hadaschik E, Sucker A, Schadendorf D, Griewank K
- 2022 Nature PMID 35790189
Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine
Niemann B, Haufs-Brusberg S, Puetz L, Feickert M, Jaeckstein MY, Hoffmann A, Zurkovic J, Heine M, Trautmann EM, Müller CE, Tönjes A, , Jafari A, Eltzschig HK, Gnad T, Blüher M, Krahmer N, Kovacs P, Heeren J, Pfeifer A
- 2022 Frontiers in cell and developmental biology PMID 35478959
Cold-Induced Lipoprotein Clearance in Cyp7b1-Deficient Mice
Evangelakos I, Kuhl A, Baguhl M, , John C, Rohde JK, Heine M, Heeren J, Worthmann A
- 2021 Molecular metabolism PMID 33516944
TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality
Sass F, , Jaeckstein MY, Pertzborn P, Schweizer M, Schinke T, Ballabio A, Scheja L, Heeren J, Fischer AW
- 2021 Cell reports First author PMID 33440156
Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution
, Fischer AW, Sass F, Worthmann A, Tödter K, Jaeckstein MY, Behrens J, Lynes MD, Kiebish MA, Narain NR, Bussberg V, Darkwah A, Jespersen NZ, Nielsen S, Scheele C, Schweizer M, Braren I, Bartelt A, Tseng YH, Heeren J, Scheja L
- 2021 Cell metabolism PMID 33357458
Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation
Fischer AW, Jaeckstein MY, Gottschling K, Heine M, Sass F, Mangels N, , Worthmann A, Bruns OT, Yuan Y, Zhu H, Chen O, Ittrich H, Nilsson SK, Stefanicka P, Ukropec J, Balaz M, Dong H, Sun W, Reimer R, Scheja L, Heeren J
- 2020 Frontiers in endocrinology PMID 33193086
Thermoneutrality-Induced Macrophage Accumulation in Brown Adipose Tissue Does Not Impair the Tissue's Competence for Cold-Induced Thermogenic Recruitment
Fischer AW, de Jong JMA, Sass F, , Heeren J, Petrovic N
- 2020 Journal of lipid research PMID 32769145
Brown adipose tissue lipoprotein and glucose disposal is not determined by thermogenesis in uncoupling protein 1-deficient mice
Fischer AW, Behrens J, Sass F, , Heine M, Pertzborn P, Scheja L, Heeren J
- 2019 Biochimica et biophysica acta. Molecular basis of disease PMID 30904610
PID1 regulates insulin-dependent glucose uptake by controlling intracellular sorting of GLUT4-storage vesicles
Fischer AW, Albers K, , Sass F, Krott LM, Schmale H, Gordts PLSM, Scheja L, Heeren J
- 2019 Nutrients PMID 30813320
Effects of Pharmacological Thermogenic Adipocyte Activation on Metabolism and Atherosclerotic Plaque Regression
Worthmann A, , Berbée JFP, Rensen PCN, Heeren J, Bartelt A
- 2019 American journal of physiology. Endocrinology and metabolism PMID 30576247
Intact innervation is essential for diet-induced recruitment of brown adipose tissue
Fischer AW, , Cannon B, Heeren J, Nedergaard J
- 2018 Cell metabolism PMID 30033199
Lipolysis Triggers a Systemic Insulin Response Essential for Efficient Energy Replenishment of Activated Brown Adipose Tissue in Mice
Heine M, Fischer AW, , Jung C, Straub LG, Gottschling K, Mangels N, Yuan Y, Nilsson SK, Liebscher G, Chen O, Schreiber R, Zechner R, Scheja L, Heeren J
- 2018 Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology PMID 29860111
Course of HEV viremia and anti-HEV IgM/IgG response in asymptomatic blood donors
Kraef C, , Hiller J, Westhölter D, Denzer U, Horvatits T, Peine S, Lohse AW, Lütgehetmann M, Polywka S, Pischke S
- 2018 The Journal of clinical investigation PMID 29408809
FoxO transcription factors are required for hepatic HDL cholesterol clearance
Lee SX, Heine M, , Ramakrishnan R, Liu J, Belnavis G, Haimi I, Fischer AW, Ginsberg HN, Heeren J, Rinninger F, Haeusler RA
- 2018 Nature medicine PMID 29400713
Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity
Bartelt A, Widenmaier SB, , Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgül G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS
- 2017 Nature medicine Correction PMID 29117173
Corrigendum: The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, , Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH
- 2017 Nature medicine PMID 28604703
Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis
Worthmann A, John C, Rühlemann MC, Baguhl M, Heinsen FA, Schaltenberg N, Heine M, , Evangelakos I, Mineo C, Fischer M, Dandri M, Kremoser C, Scheja L, Franke A, Shaul PW, Heeren J
- 2017 Nature communications PMID 28422089
Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport
Bartelt A, John C, Schaltenberg N, Berbée JFP, Worthmann A, Cherradi ML, , Piepenburg J, Boon MR, Rinninger F, Heine M, Toedter K, Niemeier A, Nilsson SK, Fischer M, Wijers SL, van Marken Lichtenbelt W, Scheja L, Rensen PCN, Heeren J
- 2017 Nature medicine PMID 28346411
The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue
Lynes MD, Leiria LO, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, , Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH
- 2016 Best practice & research. Clinical endocrinology & metabolism First author PMID 27697210
Implications of thermogenic adipose tissues for metabolic health
, Heeren J
- 2016 Nature communications PMID 27117818
Exosomal microRNA miR-92a concentration in serum reflects human brown fat activity
Chen Y, Buyel JJ, Hanssen MJ, Siegel F, Pan R, Naumann J, Schell M, van der Lans A, , Froehlich H, Heeren J, Virtanen KA, van Marken Lichtenbelt W, Pfeifer A
- 2016 Cell metabolism First author PMID 26853749
FGF21 Lowers Plasma Triglycerides by Accelerating Lipoprotein Catabolism in White and Brown Adipose Tissues
, Talukdar S, Heine M, Fischer AW, Krott LM, Nilsson SK, Brenner MB, Heeren J, Scheja L
- 2015 PloS one PMID 26695075
Genetic Dissection of Tissue-Specific Apolipoprotein E Function for Hypercholesterolemia and Diet-Induced Obesity
Wagner T, Bartelt A, , Heeren J
- 2015 Nature communications PMID 25754609
Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development
Berbée JF, Boon MR, Khedoe PP, Bartelt A, , Worthmann A, Kooijman S, Hoeke G, Mol IM, John C, Jung C, Vazirpanah N, Brouwers LP, Gordts PL, Esko JD, Hiemstra PS, Havekes LM, Scheja L, Heeren J, Rensen PC
- 2014 Atherosclerosis Co-first author PMID 24529129
Homozygosity for a partial deletion of apoprotein A-V signal peptide results in intracellular missorting of the protein and chylomicronemia in a breast-fed infant
Albers K, , Wenner K, Lohse P, Bartelt A, Heeren J, Santer R, Merkel M
26 journals · 38 papers
Grouped by topic. Each dot is a journal; the bigger the dot, the more papers we have published there.
Source: PubMed E-utilities · query Schlein C[Author]